Senior Scientist - Liquid Biopsy Assay Development (W2 Contract)

• Location: New York (Hybrid - 2-3 days on-site)
• Duration: 5 months (potential for extension or long-term engagement)
• Start: ASAP
• Engagement: W2 contract

Overview

We are seeking a Senior Scientist to join us on a contract basis to optimize and lock down our plasma-to-cell-free DNA (cfDNA) extraction pipeline ahead of commercial launch.

This is a hands-on role focused on resolving variability in automated workflows and ensuring a robust, reproducible pre-analytical process.

Key Responsibilities

• Take ownership of the plasma-to-cfDNA extraction workflow
• Diagnose and resolve batch effects and variability introduced through automation
• Optimize DNA yield, quality, and consistency across runs
• Evaluate and improve automated extraction platforms and magnetic bead-based systems
• Recommend alternative technologies, kits, or protocols where needed
• Design and implement controls to normalize batch effects
• Define and track pipeline performance metrics
• Deliver a locked, validated, and scalable workflow ready for downstream applications

Requirements

• Proven experience owning a plasma-to-cfDNA pipeline in a liquid biopsy setting
• Background in pre-analytical assay development
• Hands-on experience with automated extraction systems
• Strong understanding of magnetic bead-based workflows and failure modes
• Experience minimizing technical variability and batch effects
• Track record of implementing robust QC and normalization strategies
• Experience in leading liquid biopsy or genomics environments preferred

Outcome

You will deliver a fully optimized and reproducible cfDNA extraction pipeline with clearly defined controls and performance metrics, supporting reliable downstream analysis and commercial readiness.