Principal Scientist Upstream Process Development - Biologics
Principal Scientist, Upstream Process Development
About the Opportunity
Our client is a rapidly growing biologics-focused organization seeking a Principal Scientist to provide technical leadership within its Upstream Process Development function. This individual will lead process development activities, drive innovation, mentor junior scientists, and play a key role in advancing biologics programs from development through manufacturing.
Key Responsibilities
- Lead the design, execution, analysis, and optimization of upstream process development studies for biologics programs.
- Provide technical leadership across cross-functional development teams and support strategic project objectives.
- Oversee bioreactor operations, process scale-up activities, and technology transfers to manufacturing environments.
- Analyze experimental data, prepare technical reports, and communicate findings to internal stakeholders and leadership teams.
- Evaluate and implement new technologies, scientific advancements, and process improvements to enhance development capabilities.
Qualifications
- BS, MS, or PhD in Chemical Engineering, Biochemical Engineering, Biotechnology, or a related scientific discipline.
- Significant industry experience in upstream process development, process scale-up, and technology transfer within biotechnology, biopharmaceutical, or related environments.
- Strong expertise in mammalian cell culture, bioreactor operations, process optimization, and commercial manufacturing support.
- Experience operating within cGMP environments and supporting late-stage or commercial biologics programs.
- Demonstrated technical leadership, project management, and mentoring experience.
- Strong communication, problem-solving, and cross-functional collaboration skills.
- Experience with statistical analysis and DoE tools such as JMP, Minitab, or similar platforms is preferred.
Ideal Background
- Deep understanding of biologics process development and manufacturing.
- Proven success supporting process scale-up, technology transfer, and lifecycle management activities.
- Ability to operate in a fast-paced, scientifically driven environment while balancing multiple priorities.
- Passion for innovation, continuous improvement, and team development.
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