Principal Scientist Upstream Process Development - Biologics

Principal Scientist, Upstream Process Development

About the Opportunity

Our client is a rapidly growing biologics-focused organization seeking a Principal Scientist to provide technical leadership within its Upstream Process Development function. This individual will lead process development activities, drive innovation, mentor junior scientists, and play a key role in advancing biologics programs from development through manufacturing.

Key Responsibilities

• Lead the design, execution, analysis, and optimization of upstream process development studies for biologics programs.
• Provide technical leadership across cross-functional development teams and support strategic project objectives.
• Oversee bioreactor operations, process scale-up activities, and technology transfers to manufacturing environments.
• Analyze experimental data, prepare technical reports, and communicate findings to internal stakeholders and leadership teams.
• Evaluate and implement new technologies, scientific advancements, and process improvements to enhance development capabilities.

Qualifications

• BS, MS, or PhD in Chemical Engineering, Biochemical Engineering, Biotechnology, or a related scientific discipline.
• Significant industry experience in upstream process development, process scale-up, and technology transfer within biotechnology, biopharmaceutical, or related environments.
• Strong expertise in mammalian cell culture, bioreactor operations, process optimization, and commercial manufacturing support.
• Experience operating within cGMP environments and supporting late-stage or commercial biologics programs.
• Demonstrated technical leadership, project management, and mentoring experience.
• Strong communication, problem-solving, and cross-functional collaboration skills.
• Experience with statistical analysis and DoE tools such as JMP, Minitab, or similar platforms is preferred.

Ideal Background

• Deep understanding of biologics process development and manufacturing.
• Proven success supporting process scale-up, technology transfer, and lifecycle management activities.
• Ability to operate in a fast-paced, scientifically driven environment while balancing multiple priorities.
• Passion for innovation, continuous improvement, and team development.