We are seeking a Scientist/Senior Scientist to join our research team, responsible for overseeing, executing, and coordinating activities within the lab. This role requires extensive expertise in antibody-based therapeutics, protein engineering, molecular biology, purification, and characterization.
Key Responsibilities:
- Contribute to the engineering of novel biologic drugs, focusing on therapeutic multi-specific antibodies and Antibody Drug Conjugates (ADCs).
- Utilize structural and sequence analysis tools such as Pymol, Chimera, IgBlast, Discovery Studio, abYsis, and Geneious to guide protein and expression plasmid design.
- Assist in candidate optimization, selection, and validation of stability and critical drug-like properties.
- Perform cloning, mammalian cell line expression, purification, and characterization of protein constructs, with a focus on potential post-translational modification (PTM) sites.
- Develop comprehensive protein engineering strategies to enhance antibody stability under various physiological conditions.
- Generate homology models and evaluate properties via in silico simulation.
- Conduct protein analytics including biolayer interferometry, dynamic light scattering, SDS-PAGE, and HPLC.
- Write and review Standard Operating Procedures (SOPs) for regulatory compliance and laboratory operations.
- Collaborate with other divisions to advance company goals.
- Coordinate with R&D and manufacturing departments in China, accommodating meetings and providing technical support.
Qualifications:
- Strong scientific background in structural biology, molecular biology, biochemistry, protein purification, and characterization.
- Previous experience in therapeutic antibody engineering is essential.
If you meet these qualifications and are eager to contribute to cutting-edge research in biotechnology, we invite you to apply for this exciting opportunity. Join us as we work towards advancing novel therapies for the benefit of patients worldwide.
Benefits:
Full-time employees become eligible for benefits on the first of the month following 30 days of continuous service. These benefits include:
- Medical Insurance
- Dental Insurance
- Vision Insurance
- Employer-Paid Basic Life Insurance
- Supplemental Life Insurance
- Employer-Paid Short-Term Disability
- Long-Term Disability
- 401(k) Plan
- Paid Time Off
- Paid Holidays
