Job Description: LCMS Chemist (Part-Time, On-Site - Houston, TX)

Location: Houston, TX (On-site)
Commitment: 6-10 hours per week (approx. 3 short shifts per week)
Schedule: Flexible
Type: Part-time / Contractor
Industry: Early-stage CRO / Analytical Chemistry

About the Role

We are seeking a hands-on LCMS Chemist to support analytical operations as we establish a CRO capability in Houston. This is a highly flexible, part‑time role ideal for someone who is comfortable working independently, running instruments, and ensuring high‑quality data output.

The position's core responsibility is loading samples, operating the incubator and LCMS system, and generating data. While the day-to-day work is relatively straightforward, expertise working with relevant equipment is essential.

Candidates based in Houston are strongly preferred, as this role requires on-site presence.

Key Responsibilities

• Prepare and load samples into the incubator and LCMS instrumentation.
• Operate a high‑resolution LCMS system for small molecule analysis.
• Perform basic instrument checks and ensure runs are completed successfully.
• Monitor data generation and flag any irregularities.
• Work independently during evening or early‑morning hours, as needed.
• (For senior candidates) Provide additional scientific support or guidance as the CRO capability expands.

Requirements

Must-Have Skills

• Hands-on experience with LCMS instrumentation.
• Experience using an incubator machine in a laboratory environment.
• Ability to work independently and troubleshoot minor instrument issues.
• Comfortable with basic sample preparation and data handling.

Nice-to-Have / Preferred

• Experience with high-resolution LCMS (HRMS) for small molecules.
• Experience with triple quadrupole (TripleQuad) LCMS-acceptable if not HRMS‑specific.
• Senior-level candidates may contribute to broader CRO setup and operations.
• Prior CRO or analytical lab experience.

Work Schedule & Expectations

• Approximately 5-10 hours per week, typically over two to three short visits.
• Scheduling is flexible as long as work occurs within the 5 PM - 9 AM instrument window.
• Ideal for someone seeking a low‑hour, flexible opportunity while maintaining technical engagement.

Why Join Us

• Opportunity to contribute to the early setup of a growing CRO operation in Houston.
• Flexible working hours and minimal weekly time commitment.
• Autonomy and the ability to shape future lab processes (for senior profiles).