Founding Scientist (Longevity Research)

Founding Scientist - Genetic/Cellular Reprogramming

About the Role:
An ambitious early-stage biotech venture is seeking a visionary and highly capable Founding Scientist to lead R&D efforts in genetic reprogramming for the development of anti-aging therapeutics. The company is developing a first-in-class rejuvenation platform by integrating cutting-edge biology with AI-driven discovery tools.

This is a high-impact, founding-level opportunity with significant autonomy and leadership potential.

Key Responsibilities:

• Develop and test in vivo and in vitro anti-aging therapies using OSKM, CRISPR, or related tools
• Engineer and evaluate novel gene delivery systems (e.g., SPIT, SEND, LNPs, AAV)
• Design cyclic reprogramming protocols to induce rejuvenation without dedifferentiation
• Apply machine learning tools for:
  • Vector optimization
  • Rejuvenation biomarker prediction
  • Epigenetic clock regression
• Conduct aging-related phenotyping: epigenetic clocks, senescence, mitochondrial assays, transcriptomics
• Validate therapies in human cells and aged animal models
• Contribute to IP filings, grant applications, and technical white papers

Ideal Qualifications:

• PhD, MD/PhD, or strong MS in Molecular Biology, Aging Biology, Genetic Engineering, Synthetic Biology, or related field
• Proven experience in anti-aging, reprogramming, or regenerative medicine
• Practical knowledge of gene delivery platforms like AAV, LNPs, VLPs, or CRISPR delivery tools
• Skilled in wet-lab molecular biology: cloning, qPCR, microscopy, immunostaining, viral packaging
• Ability to independently drive full R&D projects
• Experience using machine learning, AI, or bioinformatics for biological problem-solving

Preferred Qualifications:

• Experience with SPIT, SEND, OSKM, base editing, or CRISPRa/i systems
• Familiarity with high-throughput screening, RNA-seq, or single-cell data
• Prior startup, stealth biotech, or venture-backed project experience

What's Offered:

• Founding-level equity and market-competitive compensation
• Creative freedom to shape a novel anti-aging platform
• Access to top-tier advisors in gene therapy, aging, and computational biology
• Opportunity to grow into a CSO, VP R&D, or scientific co-founder role
• Flexible work setup (remote/hybrid options available)