Founding Scientist (Longevity Research)
Founding Scientist - Genetic/Cellular Reprogramming
About the Role:
An ambitious early-stage biotech venture is seeking a visionary and highly capable Founding Scientist to lead R&D efforts in genetic reprogramming for the development of anti-aging therapeutics. The company is developing a first-in-class rejuvenation platform by integrating cutting-edge biology with AI-driven discovery tools.
This is a high-impact, founding-level opportunity with significant autonomy and leadership potential.
Key Responsibilities:
- Develop and test in vivo and in vitro anti-aging therapies using OSKM, CRISPR, or related tools
- Engineer and evaluate novel gene delivery systems (e.g., SPIT, SEND, LNPs, AAV)
- Design cyclic reprogramming protocols to induce rejuvenation without dedifferentiation
- Apply machine learning tools for:
- Vector optimization
- Rejuvenation biomarker prediction
- Epigenetic clock regression
- Conduct aging-related phenotyping: epigenetic clocks, senescence, mitochondrial assays, transcriptomics
- Validate therapies in human cells and aged animal models
- Contribute to IP filings, grant applications, and technical white papers
Ideal Qualifications:
- PhD, MD/PhD, or strong MS in Molecular Biology, Aging Biology, Genetic Engineering, Synthetic Biology, or related field
- Proven experience in anti-aging, reprogramming, or regenerative medicine
- Practical knowledge of gene delivery platforms like AAV, LNPs, VLPs, or CRISPR delivery tools
- Skilled in wet-lab molecular biology: cloning, qPCR, microscopy, immunostaining, viral packaging
- Ability to independently drive full R&D projects
- Experience using machine learning, AI, or bioinformatics for biological problem-solving
Preferred Qualifications:
- Experience with SPIT, SEND, OSKM, base editing, or CRISPRa/i systems
- Familiarity with high-throughput screening, RNA-seq, or single-cell data
- Prior startup, stealth biotech, or venture-backed project experience
What's Offered:
- Founding-level equity and market-competitive compensation
- Creative freedom to shape a novel anti-aging platform
- Access to top-tier advisors in gene therapy, aging, and computational biology
- Opportunity to grow into a CSO, VP R&D, or scientific co-founder role
- Flexible work setup (remote/hybrid options available)
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