(Senior) Scientist, MS
(Senior) Scientist, MS
Overview:
A cutting-edge biotech startup is seeking a Mass Spectrometry Scientist to lead analytical efforts across a diverse pipeline of therapeutics. This is a high-impact role for someone passionate about applying advanced analytical techniques to solve complex challenges in therapeutic development.
Key Responsibilities:
- Perform top-down proteomics for intact mass confirmation and drug-to-antibody ratio (DAR) assessments
- Conduct bottom-up peptide mapping in collaboration with chemists and protein engineers
- Analyze in vivo plasma and tissue samples via LC-MS/MS for PK quantification
- Develop and standardize data processing and reporting pipelines
- Serve as a technical liaison with external CROs and instrumentation partners
- Contribute to the build-out of internal mass spec capabilities, including equipment selection and SOP development
- Collaborate cross-functionally with chemistry, biology, and CMC teams
Qualifications:
- M.S. or Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field
- 2-5 years of experience in mass spectrometry, preferably in biologics, ADCs, or oligonucleotides
- Hands-on experience with LC-MS/MS, intact protein analysis, peptide mapping, and PK quantification
- Familiarity with conjugation chemistry and CRO management
- Strong data analysis skills using tools like Xcalibur, MassLynx, Skyline, or BioPharma Finder
Preferred Experience:
- Oligonucleotide/peptide mass spec in biological matrices
- Bioconjugation, protein engineering, or organic synthesis
- Early-stage CMC analytical development and regulatory awareness
- Comfort working in a startup environment with evolving infrastructure
What's Offered:
- Opportunity to shape analytical strategy in a fast-paced, platform-driven environment
- Competitive compensation, equity, and benefits
- A collaborative team culture rooted in scientific rigor and innovation
- Modern R&D facility equipped for high-throughput discovery and translational biology
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